Zithromax: Drug Profile

Zithromax is a semi-synthetic antibiotic, the first representative of a subclass called azalides and slightly different in structure from the classical macrolides.

» Zithromax: history of discovery

A group of researchers at the Croatian pharmaceutical company ‘Pliva’ led by Dr. Slobodan Djokic synthesized Azithromycin in 1980. It was patented in 1981, at the same time when the formula of Azithromycin was developed by scientists from Pfizer. In 1986 the manufacturers signed the agreement that gave Pfizer exclusive rights to sell Azithromycin under the brand name Zithromax in Western Europe and the United States. Pliva company acquired the rights to distribute Azithromycin in the markets in Central and Eastern Europe under the brand names of Sumamed and Azisid.

» Pharmacological action of Zithromax

Due to its main active ingredient azalide, which provides bacteriostatic effect, Zithromax acts as an antibacterial medication. Binding to 50S-ribosomal subunit, it inhibits protein synthesis and slows the growth and reproduction of bacteria down. When used in high concentrations, Zithromax has bactericidal effect. Zithromax affects extra- and intracellular pathogens. It is claimed to be effective against Gram-positive bacteria that are resistant to erythromycin.

» Zithromax is used as treatment in
the following conditions:


• Infections of the upper respiratory tract and ENT organs caused by susceptible pathogens, namely: pharyngitis, tonsillitis, laryngitis, sinusitis, otitis media, scarlet fever;

• Infections of the lower respiratory tract: pneumonia (including atypical and exacerbation of chronic pneumonia), bronchitis;

• Infections of the skin: erysipelas , impetigo, secondarily infected dermatoses;

• Urinary tract infections caused by Chlamydia trachomatis: gonorrhea and urethritis, cervicitis, Lyme disease (initial stage), peptic ulcer and duodenal ulcer associated with Helicobacter pylori.

» Contraindications for use of Zithromax

• Diarrhea (5%); • Nausea (3%);

• Abdominal pain (3%);

• Less than 1% - vomiting, melena, cholestatic jaundice, increased activity of "liver" transaminases;

• In children - constipation, decreased appetite, gastritis, oral candidiasis;

• The nervous system: dizziness, headache, vertigo, drowsiness, sensorineural hearing loss, tinnitus; in children - headache (when the medicine is used for treatment of otitis), hyperkinesia, anxiety, neurosis, sleep disturbances;

• Allergic reactions: rash, hives, itching, angioedema and bronchospasm (1 % or less).

» Overdose with Zithromax

Symptoms: severe nausea, temporary hearing loss, vomiting and diarrhea.

To avoid overdose, Zithromax should always be taken one hour before meals or 2 hours after eating. The drug is taken once a day.

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Dosage instructions for Zithromax

Adults:

• infections of the upper and lower respiratory tract – 1 dose of 0.5 g per day for 3 days;

• infections of skin and soft tissues – 1 dose of 1g per day for 2 to 5 days;

• acute urinary infections caused by Chlamydia trachomatis – 1 dose of 1 g (2 capsules of Zithromax 500mg);

• Lyme disease stage I - 1g on the first day and 1 dose of 0.5g per day for 5 days;

• gastric ulcer and duodenal ulcer caused by Helicobacter pylori – 1 dose of 1 g per day for 3 days.

Children:

• 10 mg per 1 kg of body weight taken once per day for 3 days. Alternative dosage; 10 mg per kg of body weight on the first day followed by 5.10 mg per 1 kg per day for 3 days;

• Lyme disease (stage I) - 20 mg per 1 kg of body weight on the first day and 10 mg per 1 kg of body weight for 2 to 5 days.

• Pneumonia – 1 dose of 0.5 g per day for at least 2 days and up to 7-10 days;

• Pelvic infection – 1 dose of 0.5g (2 capsules of 0.25 g) per day. Duration - 7 days.

Precautions for use of Zithromax

If you miss a dose, take it as soon as possible and continue with your regular schedule. Do not double the dose and let at least 2 hours pass between doses of Zithromax no prescription pills.

Finally, the security is not set destination (in the form of capsules and tablets) of cheap Zithromax in children and adolescents under 16 years (possibly use as an oral suspension in children from 6 months and older).