Zithromax: Drug Profile

Zithromax is a semi-synthetic antibiotic, the first representative of a subclass called azalides and slightly different in structure from the classical macrolides.

» Pharmacological action of Zithromax

Broad-spectrum antibiotic. Antibiotic-azalide, a representative of a new subgroup of macrolide antibiotics. It manifests the bactericidal effect when it reaches a high concentration in the area of inflammation. The following gram-positive cocci are susceptible to azithromycin (the active ingredient of Zithromax): Streptococcus pneumoniae, St. pyogenes, St. agalactiae, Streptococcus groups CF and G, Staphylococcus aureus, St. viridans; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B. parapertussis, Legionella pneumophila, H. ducrei, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; Some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; and Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. But Azithromycin is not active against gram positive bacteria resistant to erythromycin.

» Zithromax is used as treatment in the following conditions:

  • Infectious diseases caused by pathogens susceptible to the drug: infections of the upper respiratory tract - tonsillitis, sinusitis (inflammation of the sinuses), tonsillitis (inflammation of the tonsils / glands /), otitis media (inflammation of the middle ear cavity); scarlet fever;
  • Infections of the lower respiratory tract - bacterial and atypical pneumonia, bronchitis (inflammation of the bronchi);
  • Skin and soft tissue infections - erysipelas, impetigo (a superficial pustular skin lesions with the formation of purulent crusts), secondarily infected dermatitis (skin disease);
  • Urinary tract infections - and gonorrheal negonoreyny urethritis (inflammation of the urethra) and / or cervicitis (inflammation of the cervix);
  • Lyme disease (borreliosis - an infectious disease caused by the spirochete Borrelia).

» Contraindications for use of Zithromax

  • Diarrhea (5%);
  • Nausea (3%);
  • Abdominal pain (3%);
  • Less than 1% - vomiting, melena, cholestatic jaundice, increased activity of "liver" transaminases;
  • In children - constipation, decreased appetite, gastritis, oral candidiasis;
  • The nervous system: dizziness, headache, vertigo, drowsiness, sensorineural hearing loss, tinnitus; in children - headache (when the medicine is used for treatment of otitis), hyperkinesia, anxiety, neurosis, sleep disturbances;
  • Allergic reactions: rash, hives, itching, angioedema and bronchospasm (1 % or less).

» Overdose with Zithromax

Symptoms: severe nausea, temporary hearing loss, vomiting and diarrhea.

To avoid overdose, Zithromax should always be taken one hour before meals or 2 hours after eating. The drug is taken once a day.

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Dosage instructions for Zithromax

  • infections of the upper and lower respiratory tract – 1 dose of 0.5 g per day for 3 days;
  • infections of skin and soft tissues – 1 dose of 1g per day for 2 to 5 days;
  • acute urinary infections caused by Chlamydia trachomatis – 1 dose of 1 g (2 capsules of Zithromax 500mg);
  • Lyme disease stage I - 1g on the first day and 1 dose of 0.5g per day for 5 days;
  • gastric ulcer and duodenal ulcer caused by Helicobacter pylori – 1 dose of 1 g per day for 3 days.

  • 10 mg per 1 kg of body weight taken once per day for 3 days. Alternative dosage; 10 mg per kg of body weight on the first day followed by 5.10 mg per 1 kg per day for 3 days;
  • Lyme disease (stage I) - 20 mg per 1 kg of body weight on the first day and 10 mg per 1 kg of body weight for 2 to 5 days.
  • Pneumonia – 1 dose of 0.5 g per day for at least 2 days and up to 7-10 days;
  • Pelvic infection – 1 dose of 0.5g (2 capsules of 0.25 g) per day. Duration - 7 days.
Precautions for use of Zithromax

If you miss a dose, take it as soon as possible and continue with your regular schedule. Do not double the dose and let at least 2 hours pass between doses of Zithromax no prescription pills.

Finally, the security is not set destination (in the form of capsules and tablets) of cheap Zithromax in children and adolescents under 16 years (possibly use as an oral suspension in children from 6 months and older).